Short-wavelength radiation (rhodopsin spectrum), and the blue light hazard (excitation peak 440 nm), have been shown to have a major impact on photoreceptor and RPE function, inducing photochemical damage and apoptotic cell death. (ncbi.nlm.nih.gov)

Light exposure induced structural damage, decreased retinal pigment epithelium cell viability, and increased reactive oxygen species, senescence-associated β-galactosidase activity and matrix metalloproteinases 1 and 3 expression and secretion. Although both types of intraocular lens significantly reduced these effects, the protective effects of the ultraviolet- and blue light-absorbing intraocular lens were significantly stronger than those of the ultraviolet-absorbing intraocular lens. (ncbi.nlm.nih.gov)

• Yellow IOL material reduces light-induced ROS levels in the RPE-choroid.
• Blocking blue light reduces inflammatory cytokine mRNAs in the RPE-choroid.
• Blocking blue light reduces macrophage recruitment in the RPE-choroid.

(ncbi.nlm.nih.gov)
(sciencedirect.com)